|
KMID : 0363320150360020189
|
|
Journal of Korean Oriental Internal Medicine
2015 Volume.36 No. 2 p.189 ~ p.199
|
|
|
Component Analysis and Toxicity Study of Combined Cultivated Wild Ginseng Pharmacopuncture
|
|
Baek Sang-Hyun
Lee In-Hee
Kim Min-Jeong
Kim Eun-Ji
Ha In-Hyuk
Lee Jin-Ho
Lee Jae-Woong
|
|
|
Abstract
|
|
|
Objectives: The marker substances of cultivated wild ginseng pharmacopuncture that may not be detected during the process of steaming remain controversial. We developed a combined cultivated wild ginseng pharmacopuncture that contains all the marker substances. The aim of this experiment was to investigate the marker substances and test the toxicity of the combined cultivated wild ginseng pharmacopuncture.
Methods: The marker substances were detected using HPLC. Intravenous injection toxicity studies were conducted at Medvill, an authorized institution for non-clinical studies, under the regulations of Good Laboratory Practice. We observed survival rates, abnormal behaviors, weight changes, gross findings in autopsy, blood biochemical properties, and histological abnormalities of organs such as the liver and kidney.
Results: HPLC data showed that ginsenosides Rg1, Rb1, and Rg3 were detected at concentrations of 19.29, 47.64, and 3.02 μ g /ml, respectively. Administration of combined cultivated wild ginseng pharmacopuncture resulted in no dead animals or significant toxicological changes.
Conclusions: The combined cultivated wild ginseng pharmacopuncture contains all the marker substances and is a relatively safe treatment medium. Further studies should be conducted to confirm the present findings.
|
|
|
KEYWORD
|
|
|
combined cultivated wild ginseng pharmacopuncture, component analysis, toxicity study
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|